PLOS ONE: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation

Figure 1. Wild type and mutant IGF-1R constructs. A. IGF-1R is a heterodimeric receptor with two identical ß-subunit and two identical α-subunits. The α-subunit is completely extracellular, while the ß-subunit spans the membrane. The intracellular portion

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