A computational study of off-target effects of RNA interference A phenotype resulting from this knockdown of expression may inform about the function of the targeted gene. However, 'off-target effects' compromise the ...
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強力提升RNA干擾抑制基因效能的新方法| PanSci 泛科學 2011年3月15日 - 其中多數是無法徹底抑制基因活性，或是最後僅鎖定導致所謂"偏離標的效應"(off- target effects)之不同基因的弱觸發物。於實驗室中，上述任一腳本的 ...
Off-target effect of doublecortin family shRNA on neuronal migration ... Neuron. 2014 Jun 18;82(6):1255-62. doi: 10.1016/j.neuron.2014.04.036. Off- target effect of doublecortin family shRNA on neuronal migration associated with ...
Reduced siRNA Concentrations Lead to Fewer Off-Target Effects In addition, the Silencer Select siRNA design uses a chemical modification format that results in higher specificity knockdown and fewer off-target effects.
